研究目的
To propose and fabricate a CMOS 256-pixel self-photovoltaics-powered subretinal prosthetic chip with wide image dynamic range and shared electrodes for subretinal prostheses, addressing the limitations of previous designs in terms of dynamic range and electrode size.
研究成果
The CMOS 256-pixel self-photovoltaics-powered subretinal prosthetic chip with BDSEs and ABCCs successfully increased the stimulation charges and image dynamic range, validated through electrical measurements and in vitro experiments with Rd1 mice retinas.
研究不足
The study focuses on in vitro validation with Rd1 mice retinas, and further in vivo testing is needed to assess the chip's performance in living organisms.
1：Experimental Design and Method Selection:
The chip was designed with Adaptive Background Cancellation Circuits (ABCCs) for dynamic range enhancement and Bi-Directional Sharing Electrodes (BDSEs) for increased electrode size.
2：Sample Selection and Data Sources:
Electrical measurements and in vitro patch clamp experiments were conducted using the retinas of Rd1 mice.
3：List of Experimental Equipment and Materials:
The chip was fabricated using
4：18um CIS (CMOS Image Sensor) Technology. Experimental Procedures and Operational Workflow:
The chip's performance was validated through electrical measurement and in vitro tests.
5：Data Analysis Methods:
The stimulation frequency and injected charges were measured, and the dynamic range was calculated.
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