研究目的
To develop an effective enrichment strategy for highly diluted analytes to improve the sensitivity and detection limits of surface-enhanced Raman spectroscopy (SERS).
研究成果
The developed molecular enrichment strategy significantly improves the sensitivity of plasmonic nanosensors, enabling detection at femto- to attomolar levels. It is robust, easy to implement, and has potential applications in ultrasensitive biological sensing, environmental monitoring, and food safety.
研究不足
The strategy may require optimization for different types of analytes and solvents. The uniformity of SERS signal intensity decreases at very low analyte concentrations.
1：Experimental Design and Method Selection:
Inspired by the working principle of oil lamps, a molecular enrichment strategy was developed combining capillary action and heating evaporation.
2：Sample Selection and Data Sources:
Analyte molecules (crystal violet and anthracene) and Au nanoparticles were used.
3：List of Experimental Equipment and Materials:
Glass fiber papers, Au nanoparticles, heating plate, and Raman spectroscopy system.
4：Experimental Procedures and Operational Workflow:
A piece of GF paper was used to transport the solution containing analytes and Au NPs to a heated region where evaporation concentrated the analytes into a small area.
5：Data Analysis Methods:
SERS measurements were performed to evaluate the enrichment efficiency and detection sensitivity.
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