1：Experimental Design and Method Selection:

Three kinds of InP/ZnS QDs with different surface modifications (hQDs, aQDs, cQDs) were intravenously injected into BALB/c mice at dosages of 2.5 mg/kg BW or 25 mg/kg BW. Biodistribution was determined through cryosection fluorescence microscopy and ICP-MS analysis. Effects on histopathology, hematology, and blood biochemistry were evaluated at 1, 3, 7, 14, and 28 days post-injection.

2：5 mg/kg BW or 25 mg/kg BW. Biodistribution was determined through cryosection fluorescence microscopy and ICP-MS analysis. Effects on histopathology, hematology, and blood biochemistry were evaluated at 1, 3, 7, 14, and 28 days post-injection. Sample Selection and Data Sources:

2. Sample Selection and Data Sources: Healthy female BALB/c mice (6 weeks old) were used. Blood and organ samples were collected at specified time points.

3：List of Experimental Equipment and Materials:

Transmission electron microscopy (TEM), zeta potential and particle size analyzer, fluorescence spectrophotometer, UV/Vis spectrophotometer, ICP-MS, cryosection fluorescence microscopy equipment, automatic blood biochemical analyzer.

4：Experimental Procedures and Operational Workflow:

QDs were characterized before injection. Mice were observed for behavior, weight, and organ index changes. Blood and organ samples were collected and analyzed for QDs distribution and toxicity.

5：Data Analysis Methods:

Statistical analysis was performed using SPSS 22.0. Data were expressed as mean ± standard deviation (SD). Differences among groups were compared by one-way ANOVA.