研究目的
To develop a simple, user-friendly and inexpensive dosimeter for detecting ionizing radiation through a colorimetric nanosensor-based assay.
研究成果
The developed colorimetric nanosensor based on AuNRs and AgNPRs offers a simple, sensitive, and reproducible method for detecting ionizing radiation doses in the range of 0.5 to 20 Gy. The paper-based format enhances its applicability for widespread use in radiation therapy and environmental monitoring.
研究不足
The lower detection limit for AuNRs was 1 Gy, and for AgNPRs, it was 0.5 Gy, which may not cover all potential applications requiring detection of lower radiation doses. The study also did not explore the effects of different types of ionizing radiation beyond X-rays.
1：Experimental Design and Method Selection:
The study utilized gold nanorods (AuNRs) and silver nanoprisms (AgNPRs) as colorimetric reporters for radiation detection. The etching of these nanoparticles by hydroxyl radicals generated by ionizing radiation was monitored through changes in their localized surface plasmon resonance (LSPR) peaks and corresponding color changes.
2：Sample Selection and Data Sources:
AuNRs and AgNPRs were synthesized according to published protocols with slight modifications. The nanoparticles were characterized using UV-Vis absorption spectra, zeta potentials, and transmission electron microscopy (TEM).
3：List of Experimental Equipment and Materials:
The JL Shepherd Mark I irradiator was used for irradiation. Other equipment included a UV-vis spectrophotometer for absorption measurements, TEM for morphology assessment, and dynamic light scattering (DLS) for size measurements.
4：Experimental Procedures and Operational Workflow:
Nanoparticles were irradiated at various doses, and their absorption spectra were measured after a 2-hour incubation period. The paper-based sensor was prepared by immobilizing nanoparticles on filter paper.
5：Data Analysis Methods:
The shifts in LSPR peaks were analyzed to correlate with radiation doses. The morphological changes of nanoparticles post-irradiation were assessed using TEM and DLS.
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