研究目的
Investigating the therapeutic effects of glyceryl monooleate (GMO)-based cubic liquid crystal on skin damaged by laser.
研究成果
GMO-based cubic liquid crystals have a good repair effect on skin damage caused by laser, especially on slight and moderate damage. The underlying mechanism may depend on the GMO functions of moisture retention and improved skin fluidity. This finding provides a potential formulation for the treatment of laser skin damage.
研究不足
The study focused on the effects of GMO-based cubic liquid crystals on slight and moderate laser damage, with less emphasis on severe damage. The underlying mechanism of GMO's effect on wound healing, beyond moisture retention and improved skin fluidity, needs further exploration.
1：Experimental Design and Method Selection:
The study involved preparing GMO-based cubic liquid crystals and evaluating their characteristics. Slight, moderate, and severe laser damage models of guinea pigs were established to assess the therapeutic effect of GMO-based cubic liquid crystals.
2：Sample Selection and Data Sources:
Guinea pigs were used to establish the laser damage model. The back hair was removed before they were randomly divided into six groups based on the severity of laser injury.
3：List of Experimental Equipment and Materials:
GMO (DANSICO Co., Ltd., Denmark); ethanol (Beijing Chemical Works, Beijing, China); FITC (Fanbo Biochemicals Co., Ltd., Beijing, China).
4：Experimental Procedures and Operational Workflow:
The laser damage models were established using a dot array laser treatment instrument. The topical site with laser damage was coated with GMO-based cubic liquid crystals once daily. The damaged topical site of the skin was photographed and evaluated at various time points.
5：Data Analysis Methods:
One-way analysis of variance (ANOVA) with post hoc Tukey was used to compare the significant differences between groups. Statistical tests were performed with SPSS 18.0 software.
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small angle X-ray diffractometer
SAX Space
Anton Paar Co., Ltd.
Used to measure the structure of GMO-based cubic liquid crystals
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GMO
DANSICO Co., Ltd.
Used for preparing cubic liquid crystals
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ethanol
Beijing Chemical Works
Used in the preparation of GMO-based cubic liquid crystals
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FITC
Fanbo Biochemicals Co., Ltd.
Used to explore the different penetration depth in the skin
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polarizing light microscope
LV100NPOL
Nikon Co., Ltd.
Used to observe the anisotropy of GMO-based cubic liquid crystals
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rodent anesthesia machine
ABS
Yuyan Instruments Co., Ltd.
Used to anesthetize guinea pigs
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dot array laser treatment instrument
LS-X6
Leisi Photoelectric Technology Co., Ltd.
Used to establish laser damage models on the skin
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