研究目的
Developing rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging.
研究成果
The first 99mTc-radiolabelled small-molecule near-infrared Si-rhodamine fluorophore was successfully characterized. The technetium-99m and rhenium complexed Si-rhodamines show excellent NIR optical properties, are stable under physiological conditions, and have potential for further functionalization for selective enrichment in tumor cells and tissues.
研究不足
The molar absorption coefficient decreases dramatically after complexation, and the source of observed change in molar absorptivity was not further elucidated.
1：Experimental Design and Method Selection:
The synthesis involved modifying fluorescent Si-rhodamines to enable complexation with the Re(I)- and 99mTc(I)-tricarbonyl core.
2：Sample Selection and Data Sources:
Commercially available 3-bromo-N,N-dimethylaniline was used as the starting material.
3：List of Experimental Equipment and Materials:
Included pentacarbonylchlororhenium(I), sodium azide, and copper(I) source Cu(MeCN)4PF
4：Experimental Procedures and Operational Workflow:
The synthesis proceeded through seven steps, including a copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) and complexation with Re(I) and Tc(I).
5：Data Analysis Methods:
Optical properties were determined in various solvents, and stability was assessed in aqueous solution and human serum plasma.
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