研究目的
To evaluate the independent cross-sectional and predictive correlations of VA with DRIL in the context of other SD OCT parameters in CRVO eyes with ME receiving anti-VEGF therapy.
研究成果
Early recovery over 3 months in both DRIL and EZ parameters are key drivers of 1-year VA outcomes. Predictive models incorporating 3-month changes in DRIL and EZ disruption support their usefulness as potential robust determinants of future VA.
研究不足
The study was based on a retrospective sample, used 3 different anti-VEGF agents, and had a significant portion of baseline FA images nongradable due to macular hemorrhages. Variability in inner retinal landmarks used in DRIL measurement across studies and lack of automated algorithm to quantify DRIL and EZ integrity rapidly were also noted.
1：Experimental Design and Method Selection:
Retrospective, longitudinal cohort study design was used to assess the associations between SD OCT parameters and VA outcomes in ME secondary to CRVO.
2：Sample Selection and Data Sources:
Eighty-four patients with ME secondary to CRVO receiving pro re nata anti-VEGF therapy at 3 tertiary-level retina referral centers were included.
3：List of Experimental Equipment and Materials:
Spectralis OCT (Heidelberg Engineering) for SD OCT imaging, fluorescein angiography (FA) scans, and Adobe Photoshop for image analysis.
4：Experimental Procedures and Operational Workflow:
VA, demographic and clinical parameters, and SD OCT images from baseline, 3 months, and 12 months were reviewed. Morphologic features in the 1500-μm foveal zone were analyzed for DRIL, EZ and external limiting membrane disruption, COST visibility, cysts, subretinal and intraretinal fluid, and epiretinal membranes.
5：Data Analysis Methods:
Statistical analyses were performed using R Core Team version 3.3.1, including univariate and multivariate analyses to determine associations between SD OCT parameters and VA outcomes.
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