研究目的
Investigating the synergistic nanozymetic activity of hybrid gold bipyramid-molybdenum disulfide core@shell nanostructures for two-photon imaging and anticancer therapy.
研究成果
The AuNBPs@MoS2 hybrid demonstrated enhanced photothermal and catalytic activities, making it a promising candidate for anticancer therapy and bioimaging. The synergistic effects of photothermal therapy and catalytic therapy were effective in killing cancer cells, as evidenced by the significant reduction in cell viability.
研究不足
The study focuses on in vitro applications and the potential in vivo applications are yet to be explored. The stability and biocompatibility of the hybrid material in physiological conditions need further investigation.
1：Experimental Design and Method Selection:
The study involved the synthesis of a hybrid gold nanobipyramid nanostructure coated with molybdenum disulfide (AuNBPs@MoS2) and its characterization using various techniques.
2：Sample Selection and Data Sources:
The samples included AuNBPs, MoS2, and their hybrid AuNBPs@MoS
3：Data were acquired through FESEM, TEM, HRTEM, EDX, Raman, and UV-vis spectroscopy. List of Experimental Equipment and Materials:
Equipment used included JEOL JSM2100-F microscope, JEOL JEM-3011, LabRam HREvo 800, Varian Cary5000 UV?vis?NIR spectrophotometer, and others. Materials included HAuCl
4：3H2O, CTAB, AgNO3, ascorbic acid, and MoSExperimental Procedures and Operational Workflow:
The synthesis of AuNBPs@MoS2 involved seed-mediated growth, modification with APTES, and electrostatic interaction with MoS2 NSs. The peroxidase-like activity was measured using TMB and H2O
5：Data Analysis Methods:
The kinetic parameters were obtained using the Michaelis ? Menten model and Lineweaver ? Burk model. ROS generation was detected using TA and ABDA as molecular probes.
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