研究目的
To compare ocular lens density and transmittance measurements obtained by an improved psychophysical scotopic heterochromatic flicker photometry (sHFP) technique to the results obtained by three other measures: a psychophysical threshold technique, a Scheimpflug imaging technique, and a clinical assessment using a validated subjective scale.
研究成果
The sHFP technique offers a practical, reliable, and accurate method to measure lens density in vivo and predict lens transmittance over the visible spectrum. It is compatible with clinical and research needs for an objective quantification of lens transmittance.
研究不足
The sHFP approach relies on visual detection, so it cannot be used in visually impaired individuals. Additionally, the Beer-Lambert law results in less incident light reaching the deeper parts of the lens, which could influence the assessment of the opacity of the lens nucleus with the imaging technique.
1：Experimental Design and Method Selection:
The study compared lens density and transmittance measurements obtained by four different methods: sHFP, a psychophysical threshold technique, a Scheimpflug imaging technique, and a clinical assessment using a validated subjective scale.
2：Sample Selection and Data Sources:
Forty-three subjects (18 young, 9 middle aged, and 16 older) were included in the study.
3：List of Experimental Equipment and Materials:
The study used a full visual field covering box with a chin rest and a joystick for the threshold detection technique, a Pentacam (Oculus Optikger?te GmbH, Wetzlar, Germany) for Scheimpflug imaging, and a slit-lamp for clinical assessment.
4：Experimental Procedures and Operational Workflow:
Subjects underwent dark adaptation before testing, and lens densities were measured using the four different methods.
5：Data Analysis Methods:
Statistical analyses were performed with Statistica v10 and regression analyses with SigmaPlot v12. Lens density and opacity data were fitted as a function of age by using a quadratic trend.
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