研究目的
To elucidate the mechanism and application of PDT in cancer treatments and review strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect.
研究成果
Functional polymer nanocarriers offer a promising platform for enhancing PDT by improving the delivery and activation of photosensitizers and addressing the issue of tumor hypoxia. The review suggests that combination therapies and innovative nanocarrier designs could further improve PDT efficacy.
研究不足
The review highlights the challenges of PDT, including the hydrophobicity and non-selectivity of photosensitizers, tumor hypoxia, and limited light penetration depth. It also discusses the technical and application constraints of the experimental schemes reviewed.
