研究目的
To create microneedles with surface structures that facilitate the directional transport of liquids (drugs, vaccines) towards the tip of the microneedle, inspired by the external scent efferent system of European true bugs.
研究成果
Microneedles ornamented with bug-inspired structures can facilitate the directional transport of liquids, potentially easing the process of drug or vaccine loading onto the needles' surfaces and increasing medicine delivery efficiency. Further optimization of microstructure dimensions and distributions is needed for practical applications.
研究不足
The tip width of the microneedles was in the range of 15 – 20 μm due to setup limitations. The bug-inspired microstructures had a length larger than the CAD design due to limited axial resolution. Further optimization of writing time and 3D writing parameters is needed to improve the aspectual and mechanical qualities of the microneedles.
1：Experimental Design and Method Selection:
The study used two-photon polymerization to fabricate microneedles with bio-inspired microstructures. The design was created using SketchUp Make 2017 and processed with KISSlicer software to generate a path code for the piezo-electric stage.
2：Sample Selection and Data Sources:
Polyimide foils were irradiated to create bug-inspired structures. Microneedles were designed as pyramids with specific dimensions and ornamented with microstructures.
3：List of Experimental Equipment and Materials:
A home-made two-photon polymerization setup was used, including a Ti-sapphire femtosecond-laser, OrmoComp? resin, and OrmoDev solvent.
4：Experimental Procedures and Operational Workflow:
The laser-writing process involved uploading .gcode files to control the laser shutter and piezo stages. The 3D structures were developed by washing away the liquid phase with OrmoDev solvent.
5：Data Analysis Methods:
Scanning electron microscope images were used to analyze the fabricated microneedles and their microstructures.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
