研究目的
To develop a method for disassembling mature amyloid β aggregates using graphene oxide/carbon nitride (GO/g-C3N4) composite under UV irradiation, aiming to provide insights into the treatment of neurodegenerative diseases like Alzheimer's.
研究成果
The GO/g-C3N4 composite effectively disassembles amyloid β aggregates under UV irradiation, as evidenced by various analytical techniques. This approach provides a novel strategy for studying and potentially treating neurodegenerative diseases by targeting amyloid β aggregation.
研究不足
The study is conducted in vitro, and the applicability of GO/g-C3N4 in vivo for treating neurodegenerative diseases remains to be explored. The long-term effects and potential toxicity of the composite in biological systems need further investigation.
1：Experimental Design and Method Selection:
The study utilized GO/g-C3N4 composite as a photocatalyst for the disassembly of amyloid β aggregates under UV irradiation. Techniques like AFM, QCM, CD, and FTIR were employed to analyze the process.
2：Sample Selection and Data Sources:
Aβ(33-42) peptide was used to form aggregates, which were then treated with GO/g-C3N4 under UV light.
3：List of Experimental Equipment and Materials:
Equipment included AFM (MFP-3D-SA, Asylum Research), QCM (Q-Sense E4, Biolin Scientific), and UV irradiation setup (FUV 6 BK, Suzhou BANGWO Co., Ltd.). Materials included GO, g-C3N4, and Aβ(33-42) peptide.
4：Experimental Procedures and Operational Workflow:
Aβ(33-42) aggregates were prepared and mixed with GO/g-C3N4, then exposed to UV light. The degradation process was monitored in real-time using QCM and analyzed post-treatment with AFM, CD, and FTIR.
5：Data Analysis Methods:
Data from QCM, AFM, CD, and FTIR were analyzed to understand the degradation mechanism and structural changes in the amyloid β aggregates.
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