研究目的
To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls.
研究成果
This study confirms that RNFL thickness is reduced in AD patients compared with the control group. As a measure of neuronal degeneration, OCT should occur as a standard part of the evaluation of patients in early AD.
研究不足
The important limitation of our study is the relatively small sample. Therefore, further prospective randomized larger studies are needed to evaluate these observations.
1：Experimental Design and Method Selection:
A case-control prospective study design was used to compare RNFL thickness between AD patients and healthy controls. Spectral-domain optical coherence tomography was employed to measure RNFL thickness.
2：Sample Selection and Data Sources:
Forty untreated AD patients and 40 age-, sex-, and education-matched healthy controls were included. Subjects with certain ocular and systemic conditions were excluded.
3：List of Experimental Equipment and Materials:
Spectral-domain OCT (Spectral OCT SLO, OPKO / OTI Instrumentation), Goldmann applanation tonometry, A scan ultrasonography (Sonomed, Microscan, 100 A), ultrasonic pachymeter (Sonomed PacScan 300AP + Biometric pachymeter).
4：Experimental Procedures and Operational Workflow:
All participants underwent detailed ophthalmological and neurological examinations, including RNFL thickness measurement by OCT, on the same day.
5：Data Analysis Methods:
Statistical analyses were performed using SPSS 15.0 for Windows. Descriptive statistics, independent t-tests, and Spearman correlation coefficients were used.
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