研究目的
To quantitatively analyze corneal esthesia in patients undergoing photorefractive keratectomy (PRK) surgery.
研究成果
Corneal sensitivity recovers to near-normal levels by 90 days post-PRK in patients not receiving mitomycin C, but remains reduced by 14.9%. In patients administered mitomycin C, sensitivity does not recover to normal levels, showing a 23.59% reduction. This indicates that mitomycin C use impairs corneal nerve recovery, suggesting caution in its application during PRK.
研究不足
The study is limited by its sample size of 45 patients and short follow-up period of 90 days. It does not address long-term effects beyond 90 days or compare with other refractive procedures like LASIK. Variables such as age, iris color, and psychological state could influence results but were not fully controlled.
1：Experimental Design and Method Selection:
A prospective, longitudinal, interventional study was conducted. Corneal sensitivity was measured using a Cochet-Bonnet esthesiometer at preoperative, 30 days postoperative, and 90 days postoperative time points. Statistical analyses included descriptive measures and inferential analyses using analysis of variance and Tukey method.
2：Sample Selection and Data Sources:
45 patients over 21 years with stable ametropia, spherical equivalent between -1.50 and -8.00 D, cylindrical component <2.00 D, and normal corneal topography were enrolled. Exclusions included previous eye surgery, corneal thickness <500 μm, systemic diseases, or eye diseases affecting outcomes.
3：50 and -00 D, cylindrical component <00 D, and normal corneal topography were enrolled. Exclusions included previous eye surgery, corneal thickness <500 μm, systemic diseases, or eye diseases affecting outcomes. List of Experimental Equipment and Materials:
3. List of Experimental Equipment and Materials: Cochet-Bonnet esthesiometer, EC5000 excimer laser (Nidek Inc.), 0.02% mitomycin C, balanced saline solution, bandage contact lens, tobramycin 0.3% and dexamethasone 0.1% eye drops (Tobradex, Alcon Laboratories), ketorolac tromethamine eye drops (Acular, Alcon Laboratories).
4：02% mitomycin C, balanced saline solution, bandage contact lens, tobramycin 3% and dexamethasone 1% eye drops (Tobradex, Alcon Laboratories), ketorolac tromethamine eye drops (Acular, Alcon Laboratories). Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Patients discontinued contact lenses 2 weeks pre-surgery. Corneal sensitivity was measured in the central region with the esthesiometer. PRK surgery involved epithelial removal, photoablation with excimer laser, and mitomycin C application for high refractive error cases. Postoperative care included bandage lens and eye drops.
5：Data Analysis Methods:
Data were analyzed using Excel 2010 and R version 2.15.2. Descriptive statistics (mean, median, etc.) and inferential statistics (ANOVA, Tukey method) were applied with a significance level of 5%.
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Cochet-Bonnet esthesiometer
Measuring corneal sensitivity by evaluating the corneal touch threshold
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EC5000 excimer laser
EC5000
Nidek Inc.
Performing photoablation during PRK surgery
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Mitomycin C
0.02%
Intraoperative application to prevent haze in high refractive error cases
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Tobradex
Alcon Laboratories
Postoperative eye drops for infection and inflammation control
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Acular
Alcon Laboratories
Postoperative eye drops for pain relief
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Bandage contact lens
Protecting the cornea post-surgery
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Balanced saline solution
Washing the cornea after mitomycin C application
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