摘要： Gold nanorods (GNRs) and doxorubicin (DOX) were loaded into the lumen of halloysite nanotubes (HNTs) via a rapid synthesis process (2 min) and physical adsorption. The targeting molecules of folic acid (FA) are then conjugated to HNTs via reactions with bovine serum albumin (BSA). The formation of GNRs in HNTs was verified by different techniques. The Au-HNTs-DOX@BSA-FA shows maximum of 26.8 oC temperature rising after 8 min 808-nm laser irradiation under 0.8 W cm-2. The functionalized HNTs exhibited stronger chemotherapeutic effect under laser irradiation, since the laser could promote the release of DOX and temperature rising. Au-HNTs-DOX@BSA-FA treated MCF-7 cells exhibited survival rate of 7.4% after laser irradiation. Au-HNTs-DOX@BSA-FA treatment do not induce an obvious toxicity in blood biochemistry, liver and kidney function in normal mice. In vivo chemo-photothermal treatment towards 4T1-bearing mice suggested Au-HNTs-DOX@BSA-FA exhibited remarkable tumor-targeted efficiency and good controlled-release effect for DOX. Also, the nanoparticles exhibited a rapid photothermal performance and inhibiting ability of the growth of tumor. Due to the synergistic effect of chemical-photothermal therapy, the toxicity of DOX to normal tissues was reduced on the premise of ensuring the same curative effect with a low dosage of 0.32 mg kg-1. This novel chemo-photothermal therapy nanoplatform provided a safe, rapid, effective, and cheap choice for treatment of breast tumor both in vitro and in vivo.