研究目的
To evaluate the relationship between visual outcomes and the determinants detected by spectral domain optical coherence tomography (OCT) in eyes with epiretinal membrane (ERM) and/or taut posterior hyaloid (TPH) that underwent pars plana vitrectomy (PPV).
研究成果
Better peripapillary RNFL thickness is associated with improved visual outcomes after PPV and removal of ERM/TPH, highlighting the importance of RNFL integrity in surgical success for diabetic retinopathy complications.
研究不足
The number of patients was small (n=30), and long-term follow-up beyond 6 months was not conducted. The OCT software was designed for normal eyes, potentially affecting RNFL thickness measurements in pathological conditions. Preoperative OCT measurements were not evaluated due to segmentation uncertainties.
1:Experimental Design and Method Selection:
A prospective cohort study was conducted. Linear regression analyses were used to determine associations between OCT parameters and visual acuity.
2:Sample Selection and Data Sources:
30 patients (30 eyes) with diabetic ERM and/or TPH were included, selected based on eligibility criteria including stable OCT parameters and completed panretinal laser photocoagulation. Exclusion criteria included various ocular and systemic conditions.
3:List of Experimental Equipment and Materials:
Topcon 3D OCT-2000 for OCT imaging, Alcon Constellation vitrectomy unit for surgery, and various medications (e.g., tropicamide, Brilliant Blue dye, SF6 gas).
4:Experimental Procedures and Operational Workflow:
Patients underwent PPV with ILM peeling, OCT measurements preoperatively and postoperatively at specified intervals, and statistical analysis using SPSS software.
5:Data Analysis Methods:
Statistical analyses included Kolmogorov-Smirnov test, Wilcoxon test, Mann-Whitney U-test, and Pearson's correlation analysis.
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