研究目的
To review studies of the immunotherapy in colon cancer and immune response to PDT.
研究成果
The combination of immunotherapy and photodynamic therapy is a promising strategy for personalized colorectal cancer treatment, leveraging immunological biomarkers to enhance antitumor responses and address limitations like recurrence and metastasis. Future research should focus on clinical trials and mechanistic studies to optimize and validate this approach.
研究不足
As a review paper, it does not present original experimental data, limiting direct validation of hypotheses. It relies on the quality and scope of existing studies, which may have their own limitations such as sample sizes, model systems, or clinical applicability. The combination therapy discussed is still under research, with potential challenges in clinical translation, such as toxicity, efficacy, and personalized treatment optimization.
1：Experimental Design and Method Selection:
The paper is a review article, not an experimental study, so it does not involve a specific experimental design or method selection. It synthesizes existing literature on immunotherapy and photodynamic therapy in colorectal cancer.
2：Sample Selection and Data Sources:
Databases such as PubMed, ScienceDirect, and Springer were utilized to search for relevant articles. The review includes studies on cytokines, immune responses, and clinical trials related to colorectal cancer treatment.
3：List of Experimental Equipment and Materials:
Not applicable as this is a review paper; no specific equipment or materials are listed for experiments conducted by the authors.
4：Experimental Procedures and Operational Workflow:
Not applicable; the paper reviews and summarizes findings from other studies rather than conducting new experiments.
5：Data Analysis Methods:
The analysis involves qualitative synthesis of literature, discussing mechanisms, effects, and outcomes from various studies without statistical analysis.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容-
Photofrin
Used as a photosensitizer in photodynamic therapy for cancer treatment.
-
Foscan
Photosensitizer used in photodynamic therapy studies.
-
Bevacizumab
Monoclonal antibody that blocks VEGF, used in combination with PDT to inhibit angiogenesis.
-
Nivolumab
Immunotherapy drug approved for colorectal cancer, acts as a checkpoint inhibitor.
-
Pembrolizumab
Immunotherapy drug used in colorectal cancer treatment, targets PD-1.
-
Ipilimumab
Immunotherapy monoclonal antibody used in cancer treatment.
-
Cetuximab
Anti-EGFR monoclonal antibody used in targeted therapy for colorectal cancer.
-
Laser
690 nm laser
Used to irradiate tumors in photodynamic therapy experiments.
-
Nanoparticles
UCMSs–MC540–OVA, UCMSs–MC540–TF, Fe-TBP, Cerasomes
Used to enhance photodynamic therapy and immunotherapy by improving targeting and efficacy.
-
登录查看剩余7件设备及参数对照表
查看全部
