研究目的
To develop and validate a single open-source finite element software platform (ONELAB) for simulating both photoacoustic computed tomography (PACT) and radio frequency-induced acoustic computed tomography (RACT), enabling accurate modeling of hybrid thermoacoustic imaging for improved algorithm and hardware development.
研究成果
ONELAB is an effective single platform for simulating both PACT and RACT, accurately reconstructing optical absorption and conductivity in tissue phantoms. It provides a foundation for developing robust multimodality reconstruction algorithms and hardware systems for functional imaging, with demonstrated success in homogeneous and breast-mimicking phantoms.
研究不足
The study assumes constant Gruneisen parameter and speed of sound, which may not hold in real tissues. The time-reversal reconstruction method is approximate, especially in non-constant sound speed environments and 2D simulations. Computational efficiency is limited to single-thread processing, and the phantoms are simplified approximations of real tissues.
1：Experimental Design and Method Selection:
The study uses the ONELAB software platform, which integrates Gmsh for mesh generation and GetDP for solving partial differential equations using the finite element method (FEM). It models optical propagation via the optical diffusion equation, electromagnetic propagation via Maxwell's equations, and acoustic propagation via the time-domain wave equation. A time-reversal algorithm is employed for reconstruction.
2：Sample Selection and Data Sources:
Two phantoms are used: a homogeneous phantom with circular and elliptical absorbers, and an approximate breast phantom with glandular tissue and a tumor. Parameters are based on literature values for optical and electrical properties of tissues.
3：List of Experimental Equipment and Materials:
The primary tool is the ONELAB software (Gmsh and GetDP). Simulations are run on a Dell Precision 5820 desktop PC.
4：Experimental Procedures and Operational Workflow:
Steps include mesh creation with Gmsh, solving optical/RF equations to get fluence/electric field, calculating initial pressure, propagating acoustic waves, and reconstructing tissue parameters using time-reversal. Specific time steps and parameters are detailed for each phantom.
5：Data Analysis Methods:
Results are analyzed qualitatively through image comparisons and quantitatively by calculating relative errors in reconstructed absorption and conductivity.
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