研究目的
To assess the effect of hemodialysis on retinal and choroidal thicknesses using spectral-domain optical coherence tomography (SD-OCT).
研究成果
Hemodialysis causes a significant decrease in choroidal thickness but has no effect on retinal thickness in patients with end-stage renal disease. The decrease in choroidal thickness is likely due to fluid absorption during hemodialysis leading to reduced ocular blood flow, as the choroid has little autoregulation. Further studies with larger patient groups and additional systemic parameters are recommended.
研究不足
Serum osmolarity, plasma colloid serum osmotic pressure, and anterior segment parameters were not measured, which could be correlated with choroidal thickness changes.
1：Experimental Design and Method Selection:
A prospective interventional study design was used to evaluate changes in retinal and choroidal thicknesses before and after hemodialysis sessions in patients with end-stage renal disease. SD-OCT was employed for high-resolution imaging.
2：Sample Selection and Data Sources:
25 non-diabetic hemodialysis patients (17 male, 8 female) were enrolled based on inclusion criteria such as best corrected visual acuity exceeding 20/200, no history of chronic ocular diseases, and ultrafiltration volume >2000 mL. Exclusion criteria included ocular diseases preventing examination, recent ocular surgeries, refractive errors beyond ±
3：0 diopters, and axial length not between 22 mm and 24 mm. List of Experimental Equipment and Materials:
SD-OCT device (λ=840 nm; 26,000 A-scans/s; 5 μm axial resolution), Optovue RTVue software version
4：5, auto refractometer, Goldman applanation tonometer, and other standard ophthalmic examination tools. Experimental Procedures and Operational Workflow:
Patients underwent SD-OCT imaging just before and immediately after a 3- to 4-hour hemodialysis session. Choroidal thickness was measured at the fovea and five additional points (nasal and temporal to fovea) by two masked physicians. Retinal thickness was also measured. Systemic parameters like blood pressure and heart rate were recorded.
5：Data Analysis Methods:
Statistical analyses were performed using SPSS version 11.0. Wilcoxon test compared pre- and post-hemodialysis variables. Intraclass correlation coefficient assessed measurement reproducibility. Ocular perfusion pressure and mean arterial pressure were calculated using specific formulas.
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