研究目的
To evaluate choroidal vascularity in the eyes of patients with polypoidal choroidal vasculopathy (PCV) with and without choroidal vascular hyperpermeability (CVH).
研究成果
PCV eyes with CVH have a greater CVI and a thicker SFCT than those without CVH, indicating different choroidal features and potential differences in pathogenesis. This may explain varied outcomes in anti-VEGF treatment and suggests that PCV with CVH aligns with pachychoroid disease characteristics, while PCV without CVH does not. The similar choroidal vascularity in fellow eyes highlights the bilateral nature of PCV and the need for clinical vigilance.
研究不足
The study was limited by its retrospective nature and lack of treatment and follow-up data. OCT images were not corrected for eye size, and CVI measurements were from single 2-dimensional scans, which may not represent the entire choroidal vasculature.
1：Experimental Design and Method Selection:
A retrospective, observational case series design was used. Spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) was employed to capture choroidal images, which were then binarized using ImageJ software to calculate the choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT).
2：Sample Selection and Data Sources:
58 treatment-naive PCV patients (28 with CVH, 30 without CVH) and 30 normal controls were selected from a tertiary referral eye care center in China between January 2016 and June 2017, based on inclusion and exclusion criteria such as age >50 years, no previous treatment, and specific refractive errors.
3：List of Experimental Equipment and Materials:
SD-OCT with EDI (Spectralis HRA+OCT, Heidelberg Engineering), ImageJ software (version
4：51), and statistical software (SPSS Version 0). Experimental Procedures and Operational Workflow:
EDI-OCT scans were performed between 11:00 and 13:00 hours to minimize diurnal variations. Images were binarized by selecting a subfoveal region, measuring reflectivity, applying Niblack auto local thresholding, and calculating CVI as the ratio of luminal area to total choroidal area. SFCT was measured manually from foveal scans.
5：Data Analysis Methods:
Statistical analyses included ANOVAs for continuous variables, chi-square tests for categorical variables, paired t-tests for comparisons between eyes, and regression analyses to assess associations, with a p-value <0.05 considered significant.
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