研究目的
To compare three methods to measure center corneal clearance (CCC) during scleral lens wear: subjective (slit lamp), image processed (ImageJ) and with an optic biometer.
研究成果
The study concludes that CCC can be measured with IOLMaster, considering the systematic error found between IOLMaster and AS-OCT measurements. The three methods tested (IOLMaster, ImageJ, and slit lamp) show good correspondence, suggesting that IOLMaster and ImageJ could serve as objective techniques for CCC measurement. Additionally, the agreement between subjective and objective measures improves with the practitioner's experience.
研究不足
The study acknowledges the need for further validation of the IOLMaster technique in a larger sample and with different observers to confirm its reliability for clinical practice. The subjective nature of slit lamp measurements and the time-consuming process of digital image analysis are also noted as limitations.
1：Experimental Design and Method Selection:
The study was divided into two parts. The first part validated the use of an optic biometer (IOLMaster) for CCC measurement by comparing it with AS-OCT measurements. The second part compared three methods for CCC measurement: IOLMaster, subjective measure (Slit-Lamp), and digital image analysis (ImageJ).
2：Sample Selection and Data Sources:
Twenty-two eyes of 11 subjects with healthy corneas were recruited for the first part. For the second part, 61 eyes of 35 subjects enrolled in a clinical study were selected, including both irregular and normal corneas.
3：List of Experimental Equipment and Materials:
IOLMaster (Zeiss, Germany), AS-OCT RS-3000 (NIDEK, USA), slit lamp (CSL990 Elite 5x Digital Video, CSO, Italy), and ImageJ software (National Institutes of Health, Bethesda, Maryland, USA).
4：Experimental Procedures and Operational Workflow:
For the first part, measurements of axial length with and without scleral lenses were taken using IOLMaster, and CCC was measured with AS-OCT. For the second part, CCC was measured using IOLMaster, slit lamp, and ImageJ.
5：Data Analysis Methods:
Statistical analysis was conducted using SPSS v.25.0. Differences between techniques were estimated with Friedman test or ANOVA for repeated measurements, and correlations were assessed with Spearman’s rho.
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