研究目的
Investigating the capacities of four-dimensional optoacoustic tomography to monitor tissue heating with medium-intensity focused ultrasound (MIFU).
研究成果
Four-dimensional OA tomography enables real-time volumetric mapping of the temperature distribution during MIFU therapy, providing high sensitivity to temperature variations and high spatial resolution. This approach can greatly impact the outcome of MIFU-based medical treatments by enabling effective control of the exposure time and preventing tissue overheating.
研究不足
The monitoring depth is limited by light attenuation, and the accuracy of temperature estimation may be affected by the discrepancy between the actual location of the thermocouple tip and the analyzed OA traces.
1：Experimental Design and Method Selection:
The study involved the use of a custom-made spherical matrix array for optoacoustic (OA) volumetric temperature monitoring and a self-developed annular array probe for MIFU heating. The OA responses were excited with a short-pulsed tunable laser source.
2：Sample Selection and Data Sources:
A tissue-mimicking phantom and ex-vivo bovine tissue samples were used.
3：List of Experimental Equipment and Materials:
Custom-made spherical matrix array, annular array probe, tunable laser source, fiber bundle, needle hydrophone, thermocouple.
4：Experimental Procedures and Operational Workflow:
The MIFU array was driven with a custom-made multichannel electronic driving system. OA signals were acquired at 40 MSPS by a custom-made data acquisition system.
5：Data Analysis Methods:
OA images were reconstructed with a GPU-based three-dimensional back-projection algorithm. The temperature was estimated based on the temperature dependence of the Grüneisen parameter.
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