研究目的
To assess the difference in best-corrected visual acuity (BCVA) at presentation between the first and second eye in patients with bilateral neovascular age-related macular degeneration (AMD).
研究成果
The BCVA at the time of diagnosis of CNV was higher in the second affected eye than in the first affected eye, attributed to systematic bilateral examinations allowing earlier detection. This suggests that earlier treatment could lead to better long-term visual outcomes and improved quality of life for patients.
研究不足
Small population sample compared to other AMD studies; no investigation of nutritional supplementation or cataract status; no prospective analysis of visual acuity outcomes; lack of genetic analysis; potential biases from retrospective design.
1：Experimental Design and Method Selection:
Retrospective, single-center study reviewing clinical and imaging data for patients with neovascular AMD. Statistical analysis using Wilcoxon signed-rank test and McNemar test.
2：Sample Selection and Data Sources:
264 consecutive patients examined in January 2013 at the University Eye Clinic of Creteil, with inclusion criteria of age >50 years, exudative AMD in one eye at first presentation, and follow-up >6 months. Exclusion criteria included other maculopathies or CNV causes.
3：List of Experimental Equipment and Materials:
Spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography using Spectralis HRA (Heidelberg Engineering, Heidelberg, Germany). SAS software (Statistical Analysis Systems v
4：0, SAS Institute, Cary, NC, USA) for data analysis. Experimental Procedures and Operational Workflow:
Reviewed patient charts for demographic and clinical data, including BCVA measurements, symptom reports, and imaging results. Diagnosed active CNV via clinical examination and retinal imaging.
5：Data Analysis Methods:
Compared BCVA between eyes using Wilcoxon signed-rank test, and compared symptomatic vs. asymptomatic groups using McNemar test, with p<0.05 considered significant.
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