研究目的
To evaluate baseline predictive markers of early and late anatomical response to anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with neovascular age-related macular degeneration (nAMD).
研究成果
The presence of a peaked PED and larger CNV area are associated with early poor anatomical response to anti-VEGF treatment in nAMD patients. Aflibercept is more effective than ranibizumab in achieving better anatomical responses in both early and late treatment periods. These findings can help in predicting treatment outcomes and optimizing therapy for nAMD.
研究不足
The main limitation was the retrospective design, which may introduce selection bias, and the lack of randomization in drug choice. Additionally, the study was conducted in a real-life setting, which might affect the regularity of follow-up visits.
1：Experimental Design and Method Selection:
Retrospective, interventional, case-control study design. Methods included reviewing patient records, classifying anatomical responses, and comparing baseline demographic, fluorescein angiography (FA), and optical coherence tomography (OCT) findings among response groups. Statistical analysis was performed using SPSS software.
2：Sample Selection and Data Sources:
Included nAMD patients treated with intravitreal ranibizumab or aflibercept, who received 3 monthly loading doses and had a 12-month follow-up. Data were collected from patient records at Beyoglu Eye Training and Research Hospital.
3：List of Experimental Equipment and Materials:
Fluorescein angiography (FA) was performed using HRA-2 (Heidelberg Engineering), optical coherence tomography (OCT) using Spectralis (Heidelberg Engineering), intravitreal injections with ranibizumab or aflibercept, and povidone-iodine (Betadine; Purdue Pharma) for sterilization.
4：Experimental Procedures and Operational Workflow:
Patients underwent baseline examinations including BCVA measurement, slit-lamp biomicroscopy, IOP measurement, FA, and OCT. They received 3 monthly anti-VEGF injections, followed by monthly follow-up visits. Anatomical response was assessed at month 3 and between months 3 and 12 based on OCT findings.
5：Data Analysis Methods:
Statistical analysis included one-way ANOVA, chi-square tests, and paired samples t-tests using SPSS Version 21.0. P-value < 0.05 was considered significant.
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