研究目的
To develop and demonstrate a soft hybrid nanorobot (nanoeel) that mimics an electric eel for targeted and on-demand drug delivery using magnetically coupled piezoelectric effects.
研究成果
The hybrid nanoeels can be magnetically actuated for targeted drug delivery with on-demand release capabilities. By tuning magnetic parameters, propulsion and drug release can be controlled, minimizing side effects on healthy tissue. This approach demonstrates the potential for biologically inspired nanodevices in biomedical applications.
研究不足
The scale of the device is small, making on-board integration of multiple functional components challenging. Fabrication and manipulation complexities may limit scalability. Biocompatibility is confirmed only up to 100 ppm concentration, and in vitro experiments are conducted with custom setups, which may not fully replicate in vivo conditions.
1：Experimental Design and Method Selection:
The study employs coaxial lithography (COAL) for fabrication, using anodized aluminum oxide (AAO) templates. Magnetic actuation is used to induce piezoelectric effects for drug release and locomotion.
2：Sample Selection and Data Sources:
Hybrid nanoeels are fabricated with specific materials (e.g., PVDF-based copolymers, polypyrrole nanowires, nickel rings). Drug release is studied using rhodamine-B and doxorubicin as model drugs.
3：List of Experimental Equipment and Materials:
Includes AAO templates, electrodeposition setups, SEM, TEM, STEM, EDX, XRD, magnetic manipulation system with electromagnets, fluorescence microscope, UV-vis spectrophotometer, MTT assay kits, and various chemicals (e.g., PVDF-TrFE, P(VDF-HFP), polydopamine).
4：Experimental Procedures and Operational Workflow:
Fabrication involves electrodeposition of materials in AAO templates, vacuum infiltration for PVDF, wet etching for release. Magnetic fields of specific strengths and frequencies are applied to study swimming and drug release. Drug loading involves polydopamine treatment and incubation with drugs.
5：Data Analysis Methods:
Data is analyzed using SEM/TEM for morphology, EDX/XRD for composition, velocity measurements from videos, UV-vis for drug release quantification, and MTT assays for biocompatibility.
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SEM
ULTRA 55
Zeiss
Characterization of morphology of hybrid nanostructures.
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TEM
F30
FEI
Transmission electron microscopy for detailed imaging.
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STEM
F30
FEI
Scanning transmission electron microscopy for elemental mapping.
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Fluorescence microscope
IX 81
Olympus
Imaging and recording of manipulated structures under magnetic fields.
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AUTOLAB PGSTAT302N
PGSTAT302N
AUTOLAB
Electrodeposition setup for fabricating materials.
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AAO template
Anodisc
Whatman
Template for fabricating nanowires via electrodeposition and infiltration.
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EDX
Energy-dispersive X-ray analysis for elemental distribution.
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XRD
X-ray diffraction analysis for material composition confirmation.
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Magnetic manipulation system
Produces rotating magnetic fields for actuation and drug release studies.
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UV-vis spectrophotometer
Infinite 200 Pro
Tecan
Quantification of drug release by measuring absorbance.
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MTT assay kit
Biocompatibility testing using MTT cytotoxicity study.
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